Should P2Y12 inhibitors be given for 12 months in acute coronary syndrome?
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Within the past years, five moderate-sized randomized controlled trials evaluated different DAPT durations after percutaneous coronary intervention. These studies included a significant percentage of ACS patients that varied from 30 to 75% depending on the study. Results suggest that in selected populations prolonging DAPT does not offer additional protection from ischemic events and increases bleeding complications. However, results from a large-scale registry illustrate that DAPT durations beyond 6 months are associated with lower cardiovascular risk. Moreover, a multicenter registry demonstrated that the context underlying DAPT cessation is an additional correlate of outcomes after stent implantation.

Curr Opin Cardiol. 2014 Jul;29(4):301-6. doi: 10.1097/HCO.0000000000000070.

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Dr. Georgios Christodoulidis

Usman Baber, Roxana Mehran

PMID: 24842783

DOI: 10.1097 / HCO.0000000000000070